| Abstrakt: |
Researchers from Southern Medical University have developed mesoporous superparamagnetic iron oxide nanoparticles (MSPIONs) as a drug delivery system for tumor ferroptosis therapy. The MSPIONs have an average diameter of 70 nm and a pore size of 3.9 nm, allowing for high drug loading content. The researchers loaded sorafenib (SFN) and/or brequinar (BQR) into the mesopores of MSPIONs, creating SFN@MSPION, BQR@MSPION, and SFN/BQR@MSPION with high drug loading content. The released components in the tumor microenvironment can enhance oxidative stress and reactive oxygen species levels, making MSPIONs a promising therapeutic option for tumors. The study verified the therapeutic mechanism, efficacy, and biosafety of MSPION-based drug delivery systems on tumor cells and tumor-bearing mice. [Extracted from the article] |
