| Abstrakt: |
A study conducted by researchers at Shenzhen University in China focuses on tuberculous meningitis (TBM), a severe form of tuberculosis that affects the central nervous system. The study used single-cell RNA sequencing to analyze cells from children with TBM and identified 33 monocyte populations, including CD4_C04 cells with Th17 and Th1 phenotypes and Macro_C01 cells with a microglia phenotype. The researchers found that complement-activated microglial Macro_C01 cells were associated with a neuroinflammatory response that contributes to persistent meningitis. The study suggests that these cells interact with CD4_C04 cells to amplify inflammatory signals, potentially leading to hyperinflammation. [Extracted from the article] |
