Discovery of novel melatonin-mydroxyquinoline hybrids as multitarget strategies for Alzheimer's disease therapy.

Autor:	Wei Wang, Tingting Pan, Rui Su, Mingbin Chen, Wandi Xiong, Congjun Xu, Ling Huang, Wenbao Wang, Yunlei Hou, Zhenghui Kang, Gaofei Wei,
Předmět:	MELATONIN ALZHEIMER'S disease treatment NATURAL products HYDROGEN peroxide OXIDATIVE stress
Zdroj:	Frontiers in Chemistry; 2024, p01-11, 11p
Abstrakt:	Alzheimer's disease (AD) is a neurodegenerative disease that seriously affects human health, and current treatment strategies are far from meeting clinical needs. Inspired by multi-target drug design strategies, a series of novel natural products-based melatonin-hydroxyquinoline hybrids were designed and synthesized, targeting anti-oxidation and metal-chelating at the same time. Most of the compounds showed significant oxygen radical absorbance capacity and Aβ1-42 aggregation inhibition. Moreover, the compounds possess good blood-brain barrier permeability. 6b and 6c have a good ability to alleviate oxidative stress induced by hydrogen peroxide. 6b and 6c possess metal-chelating properties with the chelation ratio being 2:1. Furthermore, 6b can significantly mitigate metal-induced Aβ aggregation. This work may provide a new multi-target treatment strategy for Alzheimer's disease. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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