Pyrogallol experimentally and theoretically suppressed advanced glycation end products (AGEs) formation, as one of the mechanisms involved in the chronic complications of the diabetes.

Autor:	Dorali Beni, Ashkan, Bahramikia, Seifollah
Předmět:	DIABETES complications COMPUTER-assisted molecular modeling BLOOD proteins OXIDATIVE stress REACTIVE oxygen species PHENOLS ADVANCED glycation end-products MOLECULAR structure SERUM albumin CELL receptors
Zdroj:	Journal of Asian Natural Products Research; Jun2024, Vol. 26 Issue 6, p726-738, 13p
Abstrakt:	This study aimed to explore the inhibitory effect of pyrogallol on AGE formation in the bovine serum albumin (BSA)/glucose system for 21 days at 37 °C. The AGEs formation was measured in terms of Amadori products, total AGEs, argpyrimidine, and pentosidine. Molecular docking was used to investigate the interaction between pyrogallol and BSA. According to the results, in the presence of pyrogallol, the formation of pentosidine and argpyrimidine AGEs decreased. The molecular interaction studies demonstrated that pyrogallol has a high affinity towards arginine residues of albumin. Finally, results proved pyrogallol is a vigorous antiglycation compound and fruitful for AGE inhibition. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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