Peripheral microvascular function is linked to cardiac involvement on cardiovascular magnetic resonance in systemic sclerosis–related pulmonary arterial hypertension.

Autor:	Vos, Jacqueline L, Lemmers, Jacqueline M J, Messaoudi, Saloua El, Snoeren, Miranda, Dijk, Arie P J van, Duijnhouwer, Anthonie L, Rodwell, Laura, Leuven, Sander I van, Post, Martijn C, Vonk, Madelon C, Nijveldt, Robin
Předmět:	CARDIOVASCULAR system radiography CROSS-sectional method STATISTICAL correlation MORTALITY DIAGNOSTIC imaging PERIPHERAL vascular diseases ADENOSINES EDEMA SEVERITY of illness index MAGNETIC resonance imaging DESCRIPTIVE statistics PERFUSION imaging FIBROSIS SYSTEMIC scleroderma HYPEREMIA RESEARCH DIASTOLIC blood pressure PULMONARY arterial hypertension MICROSCOPY COMPARATIVE studies PERFUSION INFLAMMATION ECHOCARDIOGRAPHY EVALUATION
Zdroj:	European Heart Journal - Cardiovascular Imaging; May2024, Vol. 25 Issue 5, p708-717, 10p
Abstrakt:	Aims Systemic sclerosis (SSc) is characterized by vasculopathy, inflammation, and fibrosis, and carries one of the worst prognoses if patients also develop pulmonary arterial hypertension (PAH). Although PAH is a known prognosticator, patients with SSc–PAH demonstrate disproportionately high mortality, presumably due to cardiac involvement. In this cross-sectional study, the relationship between cardiac involvement revealed by cardiovascular magnetic resonance (CMR) and systemic microvascular disease severity measured with nailfold capillaromicroscopy (NCM) in patients with SSc–PAH is evaluated and compared with patients with idiopathic PAH (IPAH). Methods and results Patients with SSc–PAH and IPAH underwent CMR, echocardiography, and NCM with post-occlusive reactivity hyperaemia (PORH) testing on the same day. CMR imaging included T2 (oedema), native, and post-contrast T1 mapping to measure the extracellular volume fraction (ECV, fibrosis) and adenosine-stress-perfusion imaging measuring the relative myocardial upslope (microvascular coronary perfusion). Measures of peripheral microvascular function were related to CMR indices of oedema, fibrosis, and myocardial perfusion. SSc-PAH patients (n = 20) had higher T2 values and a trend towards a higher ECV, compared with IPAH patients (n = 5), and a lower nailfold capillary density (NCD) and reduced capillary recruitment after PORH. NCD correlated with ECV and T2 (r = −0.443 and −0.464, respectively, P < 0.05 for both) and with markers of diastolic dysfunction on echocardiography. PORH testing, but not NCD, correlated with the relative myocardial upslope (r = 0.421, P < 0.05). Conclusion SSc-PAH patients showed higher markers of cardiac fibrosis and inflammation, compared with IPAH patients. These markers correlated well with peripheral microvascular dysfunction, suggesting that SSc-driven inflammation and vasculopathy concurrently affect peripheral microcirculation and the heart. This may contribute to the disproportionate high mortality in SSc–PAH. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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