| Autor: |
Han, Cheng-Long, Tian, Bao-Wen, Yan, Lun-Jie, Ding, Zi-Niu, Liu, Hui, Pan, Guo-Qiang, Zhang, Xiao, Mao, Xin-Chen, Tan, Si-Yu, Li, Rui-Zhe, Wang, Dong-Xu, Dong, Zhao-Ru, Yan, Yu-Chuan, Li, Tao |
| Předmět: |
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| Zdroj: |
Expert Review of Anticancer Therapy; May2024, Vol. 24 Issue 5, p303-312, 10p |
| Abstrakt: |
The effect of age, sex, and eastern cooperative oncology group performance status (ECOG PS) on the efficacy and safety of immune checkpoint inhibitor (ICI) therapy among hepatocellular carcinoma (HCC) patients remains elusive. Thus, a meta-analysis was conducted to evaluate whether such effects exist. Eligible studies in PubMed, Embase, and Cochrane Library databases were retrieved. One-hundred-and-eleven studies involving 14,768 HCC patients were included. The findings indicated that the ECOG PS didn't have a significant effect on the ORR and PFS in ICI-treated HCC patients (higher ECOG PS vs. lower ECOG PS: ORR: OR = 0.78, 95%CI = 0.55–1.10; PFS: HR = 1.15, 95%CI = 0.97–1.35), while those patients with a higher ECOG PS may have a worse OS (HR = 1.52, 95% CI = 1.26–1.84). There is no significant evidence of the effect of age (older vs. younger) or sex (males vs. females) on the efficacy of ICI therapy in HCC. ICI therapy in HCC should not be restricted strictly to certain patients in age or sex categories, while HCC patients with higher ECOG PS may require closer medication or follow-up strategy during ICI therapy. CRD42024518407 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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