| Abstrakt: |
Breast cancer is the second most common cancer in females; therefore, the prevalence of multi-drug and methicillin-resistant Staphylococcus aureus may lead to increase mortality and morbidity rates among women with breast cancer. The present study aimed to identify the prevalence of multiple drug-resistant Staphylococcus aureus among breast cancer patients. From November (2019) to January (2020), 216 random patients with breast cancer enrolled in an oncology center in Babylon City, Iraq. Among the 130 Staphylococcus aureus isolates, 40 (30.7%) isolates carried the mecA gene using the polymerase chain reaction technique. 9 (22.5%), 5 (12.5%), 5 (12.5%), 3 (7.5%), and 3 (7.5%) of multi-drug and methicillin-resistant isolates were detected to be resistant to 3, 5, 6, 4 and 7 classes of antibiotics, respectively. Multiple antimicrobial resistance index values for multi-drug resistant isolates ranged from 0.3 to 0.6. In the current investigation, it was found that Staphylococcus aureus was the most common cause of infections associated with breast cancer, and the prevalence of multidrug- and methicillin-resistant Staphylococcus isolates is of concern because it may cause complications and may lead to death, as these bacteria possess high virulence characteristics such as resistance to β-lactams and multiple resistance to non-β-lactams. According to the findings the results of the current study and definitions of multiple drug resistance, the isolates of methicillin-resistant Staphylococcus aureus were multi-resistant isolates, but they did not possess extensive and pandrug resistance, because the isolates were resistant to at least three to seven classes of antibiotics, but there were no isolates resistant to most or all of the antibiotics. [ABSTRACT FROM AUTHOR] |
