Risk Factors for Treatment Failure in Neonates With Skin and Soft Tissue Infection: A Retrospective Cohort Study.
| Autor: | Patel, Purva, Foster, Catherine E., Stimes, Grant, Lee, Su Rin, Wallace, Sowdhamini S. |
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| Předmět: |
ANTIBIOTICS
SOFT tissue infections COMMUNICABLE diseases RISK assessment CELLULITIS SKIN diseases RETROSPECTIVE studies HOSPITAL emergency services TERTIARY care ORAL drug administration METHICILLIN-resistant staphylococcus aureus LONGITUDINAL method ODDS ratio CLINDAMYCIN MEDICAL records ACQUISITION of data ABSCESSES TREATMENT failure CONFIDENCE intervals MASTITIS CHILDREN |
| Zdroj: | Clinical Pediatrics; Jun2024, Vol. 63 Issue 5, p689-696, 8p |
| Abstrakt: | We aimed to describe the frequency of treatment failure and associated risk factors for treatment failure amongst neonates with skin and soft tissue infections (SSTIs). We conducted a retrospective cohort study of neonates 0 to 28 days old with uncomplicated SSTIs presenting to the emergency department of a quaternary care children's hospital from 2009 to 2017. Data were collected via chart review. Skin and soft tissue infections included the following: cellulitis, abscess, mastitis, perirectal SSTI, carbuncle, and furuncle. Of the 202 neonates in the study, most were term, afebrile with mastitis, or perirectal SSTI. Treatment failure occurred in 8% (17/202) of neonates receiving oral antibiotics; 10 of these neonates had perirectal SSTIs and 2 had clindamycin and methicillin-resistant Staphylococcus aureus. Neonates with treatment failure had increased odds of having perirectal SSTIs (odds ratio [OR] = 4.08, 95% confidence interval [CI] = 1.46-11.31). Further studies are needed to identify strategies to prevent treatment failure in neonates with perirectal SSTIs. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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