| Abstrakt: |
Background: The increasing popularity of minimally invasive aesthetic surgery has led to the ongoing development of new tissue fillers. These substances require a long-term safety assessment. One of the new fillers introduced to the market is a copolyamide-based gel called Aquafilling, subsequently renamed as Los Deline. In this review, we analyze the updated published information concerning this substance. Methods: 734 articles published within the last 20 years were retrieved from the databases of PubMed, Scopus, Embase, and Google Scholar. Thirty articles describing 251 patients met the inclusion criteria. Results : The most common complications were induration, firmness, pain, and gel migration. Twenty articles reported inflammation resulting from gel injection. The most common imaging method was MRI combined with USG. Six out of eight studies describing laboratory findings reported no elevation of CRP, WBC or ESR. The treatments with the lowest rates of reoperation were mastectomy and radical surgery (massive irrigation and infiltrating tissue excision). There was significant heterogeneity of pathogens obtained from gel-derived swabs. Conclusions: Over time, Aquafilling injection can potentially result in a variety of complications. It triggers inflammation and prophylactic removal should be considered. MRI and USG are recommended in the diagnostic process. Elevated CRP, WBC, or ESR indicate the presence of comorbidity or advanced gel infection. The recommended treatment is radical surgery. There is not enough information available in the literature about reconstruction, especially regarding immediate reconstruction. Antibiotics should be administered according to the antibiogram, with ciprofloxacin and clindamycin being considered if empirical treatment is needed; however, further research is required. Level of evidence: Not ratable [ABSTRACT FROM AUTHOR] |
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