Research from University of Granada Provides New Study Findings on Tissue Engineering (Genipin crosslinking promotes biomechanical reinforcement and pro-regenerative macrophage polarization in bioartificial tubular substitutes).

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Zdroj: Blood Weekly; 5/9/2024, p365-365, 1p
Abstrakt: A recent study conducted by researchers at the University of Granada focused on tissue engineering for nerve repair. The study explored the use of genipin crosslinking to enhance the mechanical properties of bioartificial nerve substitutes made from fibrin-agarose hydrogels. The researchers found that genipin crosslinking improved the biomechanical resistance of the substitutes without altering their structure. Additionally, the crosslinked substitutes promoted a shift in macrophage polarization from a pro-inflammatory to a pro-regenerative phenotype. These findings suggest that genipin-crosslinked tubular substitutes could be beneficial for nerve repair and other tissue engineering applications. [Extracted from the article]
Databáze: Complementary Index