| Abstrakt: |
A recent study conducted by researchers at Boston University focused on the role of B cells in protecting against respiratory pneumococcal infections. The study found that recovery from these infections leads to localized protection in the lungs, mediated by resident memory lymphocytes. The researchers discovered that re-exposure to the bacteria is necessary for the accumulation of dynamic and heterogeneous populations of B cells in the lung, which are essential for the establishment of lung resident memory B cells. CD4+ T cells and CD40L signaling were found to be critical for the establishment of these cells, while CXCL13 signaling was not. The findings suggest that CD40L signaling from antigen-stimulated CD4+ T cells is crucial for the establishment of local resident memory B cells, which protect against future infections. [Extracted from the article] |
