| Abstrakt: |
A new study on antimicrobials has been published by a researcher from the University of Valle in Cali, Colombia. The study focuses on the design and synthesis of metallopeptides targeting DNA, which have emerged as an alternative to conventional antibiotics. The researchers synthesized copper(II) metallopeptides and evaluated their antimicrobial activity against Gram-positive and Gram-negative bacteria. The results showed that the metal center in the metallopeptides increased their antimicrobial activity. The study also investigated the interactions of the metallopeptides with plasmid DNA and found that they efficiently interacted with the DNA, inhibiting its replication. Molecular dynamics and docking simulations were performed to understand the interactions of the compounds with DNA. The study concludes that the metallopeptides show potential as antimicrobial agents with a higher binding affinity to DNA. [Extracted from the article] |
