| Abstrakt: |
A recent study from the University of Michigan focuses on cell surface receptors, specifically G-protein-coupled receptors (GPCRs). GPCRs play a crucial role in transmitting the effects of various neuromodulators in the brain. The researchers developed single-protein chain integrator sensors that can be used to determine the localization of GPCR agonists in the brain. They successfully engineered sensors for multiple GPCRs, including the mu-opioid receptor, kappa-opioid receptor, beta 2-adrenergic receptor, dopamine receptor D1, and cholinergic receptor muscarinic 2 agonists. The study demonstrates the potential of these sensors for detecting synthetic and endogenous neuromodulators in the brain. [Extracted from the article] |
