University of Birmingham Researchers Target Head and Neck Cancer (Circulating tumour DNA detects somatic variants contributing to spatial and temporal intra-tumoural heterogeneity in head and neck squamous cell carcinoma).

Předmět:	CELL-free DNA SQUAMOUS cell carcinoma CIRCULATING tumor DNA RESEARCH personnel CANCER genetics HETEROGENEITY
Zdroj:	Genomics & Genetics Weekly; 5/10/2024, p1405-1405, 1p
Abstrakt:	Researchers from the University of Birmingham have conducted a study on head and neck squamous cell carcinoma (HNSCC) to investigate the use of circulating tumor DNA (ctDNA) in detecting genomic intra-tumoral heterogeneity (ITH). The study found high rates of genomic ITH among the patients, with ctDNA identifying a significant proportion of tumor-specific variants. Serial sampling of ctDNA also allowed for post-treatment surveillance and early detection of treatment failure. This research contributes to the understanding of HNSCC and the potential utility of ctDNA in its diagnosis and monitoring. [Extracted from the article]
Databáze:	Complementary Index
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