Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with Benzyl Halides.

Autor:	Nikitina, P. A., Os'kina, I. A., Nikolaenkova, E. B., Kulikova, E. A., Miroshnikov, V. S., Perevalov, V. P., Tikhonov, A. Ya.
Předmět:	BENZYL halides CONDENSATION reactions ALKYLATION IMIDAZOLES ALKOXY compounds
Zdroj:	Russian Journal of Organic Chemistry; Feb2024, Vol. 60 Issue 2, p243-251, 9p
Abstrakt:	The alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl halides resulted in the selective formation of O-alkoxy derivatives. N-Alkylation products (1-alkylimidazole 3-oxides) were obtained by the condensation reaction from acyclic starting compounds. In the presence of the 2-hydroxyphenyl substituent in the 2-position of the imidazole ring, selective monoalkylation involving the hydroxyl substituent on the imidazole nitrogen takes place. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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