| Autor: |
Li, Jingli, Sun, Jian, Liu, Lingjing, Zhang, Chunyi, Liu, Zixiang |
| Předmět: |
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| Zdroj: |
British Journal of Nutrition; 5/28/2024, Vol. 131 Issue 10, p1720-1729, 10p |
| Abstrakt: |
This study aimed to investigate the association between n -3 PUFA and lung function. First, a cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES) 2007–2012 data. n -3 PUFA intake was obtained from 24-h dietary recalls. A multivariable linear regression model was used to assess the observational associations of n -3 PUFA intake with lung function. Subsequently, a two-sample Mendelian randomisation (MR) was performed to estimate the potential causal effect of n -3 PUFA on lung function. Genetic instrumental variables were extracted from published genome-wide association studies. Summary statistics about n -3 PUFA was from UK Biobank. Inverse variance weighted was the primary analysis approach. The observational study did not demonstrate a significant association between n -3 PUFA intake and most lung function measures; however, a notable exception was observed with significant findings in the highest quartile for forced vital capacity (FVC) and % predicted FVC. The MR results also showed no causal effect of circulating n -3 PUFA concentration on lung function (forced expiratory volume in one second (FEV1), β = 0·01301, se = 0·01932, P = 0·5006; FVC, β = −0·001894, se = 0·01704, P = 0·9115; FEV1:FVC, β = 0·03118, se = 0·01743, P = 0·07359). These findings indicate the need for further investigation into the impact of higher n -3 PUFA consumption on lung health. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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