| Autor: |
Schoenmakers, Tom, Leers, Mathie P.G., Deneer, Ruben, van Rosmalen, Frank, Gorissen, Stefan H.M., Verboeket-van de Venne, Wilhelmine P.H.G., Vojinovic, Una, van Mook, Walther N.K.A., Wolffs, Petra F.G., van Bussel, Bas C.T., van Loo, Inge H.M. |
| Předmět: |
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| Zdroj: |
Clinical Chemistry & Laboratory Medicine; May2024, Vol. 62 Issue 6, p1228-1236, 9p |
| Abstrakt: |
The present study examines the temporal association between the changes in SARS-CoV-2 viral load during infection and whether the CoLab-score can facilitate de-isolation. Nasal swabs and blood samples were collected from ICU-admitted SARS-CoV-2 positive patients at Maastricht UMC+ from March 25, 2020 to October 1, 2021. The CoLab-score was calculated based on 10 blood parameters and age and can range from −43 to 6. Three mixed effects analyses compared patient categories based on initial PCR Ct values (low; Ct≤20, mid; 20>Ct≤30, high; Ct>30), serial PCR Ct values to CoLab-scores over time, and the association between within-patient delta Ct values and CoLab-scores. In 324 patients, the median Ct was 33, and the median CoLab-score was −1.78. Mid (n=110) and low (n=41) Ct-categories had higher CoLab-scores over time (+0.60 points, 95 % CI; 0.04–1.17, and +0.28 points, 95 % CI −0.49 to 1.04) compared to the high Ct (n=87) category. Over time, higher serial Ct values were associated with lower serial CoLab-scores, decreasing by −0.07 points (95 % CI; −0.11 to −0.02) per day. Increasing delta Ct values were associated with a decreasing delta CoLab-score of −0.12 (95 % CI; −0.23; −0.01). The study found an association between lower viral load on admission and reduced CoLab-score. Additionally, a decrease in viral load over time was associated with a decrease in CoLab-score. Therefore, the CoLab-score may make patient de-isolation an option based on the CoLab-score. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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