Multidrug-Resistant Bacterial Infections in Pediatric Patients Hospitalized at King Abdulaziz University Hospital, Jeddah, Western Saudi Arabia.

Autor:	Saeedi, Fajr A., Hegazi, Moustafa A., Alsaedi, Hani, Alganmi, Ahmed Hussain, Mokhtar, Jawahir A., Metwalli, Eilaf Majdi, Hamadallah, Hanaa, Siam, Ghassan S., Alaqla, Abdullah, Alsharabi, Abdullah, Alotaibi, Sultan Ahmed
Předmět:	BACTERIAL disease risk factors CHILDREN'S health CROSS-sectional method ADRENOCORTICAL hormones ACADEMIC medical centers PHENOMENOLOGICAL biology CROSS infection STAPHYLOCOCCAL diseases MICROBIAL sensitivity tests FISHER exact test NEONATAL intensive care units BLOODBORNE infections CATHETER-related infections PATIENT readmissions MULTIDRUG resistance RETROSPECTIVE studies DESCRIPTIVE statistics CHI-squared test MANN Whitney U Test NEONATAL intensive care VENTILATOR-associated pneumonia CENTRAL venous catheterization PEDIATRICS KLEBSIELLA infections MEDICAL records ACQUISITION of data ELECTRONIC health records INTENSIVE care units ARTIFICIAL respiration BACTERIAL diseases MICROBIOLOGY DATA analysis software CARBAPENEM-resistant bacteria LENGTH of stay in hospitals HOSPITAL care of children NEONATAL sepsis COMORBIDITY
Zdroj:	Children; Apr2024, Vol. 11 Issue 4, p444, 14p
Abstrakt:	Multidrug-resistant bacterial infections (MDRIs) constitute a major global threat due to increased patient morbidity/mortality and hospital stay/healthcare costs. A few studies from KSA, including our locality, addressed antimicrobial resistance in pediatric patients. This study was performed to recognize the incidence and clinical/microbiologic features of MDRIs in hospitalized pediatric patients. A retrospective cross-sectional study included pediatric patients < 18 years, admitted to King Abdulaziz University Hospital, between October 2021 and November 2022, with confirmed positive cultures of bacteria isolated from blood/body fluids. Patients' medical files provided the required data. MDR organisms (MDROs) were identified in 12.8% of the total cultures. The incidence of MDRIs was relatively high, as it was detected in 42% of patients and in 54.3% of positive bacterial cultures especially among critically ill patients admitted to the NICU and PICU. Pneumonia/ventilator-associated pneumonia was the main type of infection in 37.8% of patients with MDROs. Klebsiella pneumoniae was the most common significantly isolated MDRO in 39.5% of MDR cultures. Interestingly, a low weight for (no need for their as terminology weight for age is standard and well-known) was the only significant risk factor associated with MDROs (p = 0.02). Mortality was significantly higher (p = 0.001) in patients with MDROs (32.4%) than in patients without MDROs (3.9%). Patients who died including 85.7% of patients with MDROs had significantly longer durations of admission, more cultures, and utilized a larger number of antibiotics than the surviving patients (p = 0.02, p = 0.01, p = 0.04, respectively). This study provided a comprehensive update on the seriously alarming problem of MDROs, and its impacts on pediatric patients. The detected findings are crucial and are a helpful guide to decid for implementing effective strategies to mitigate MDROs. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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