Pumping up the Fight against Multiple Sclerosis: The Effects of High-Intensity Resistance Training on Functional Capacity, Muscle Mass, and Axonal Damage.
| Autor: | Maroto-Izquierdo, Sergio, Mulero, Patricia, Menéndez, Héctor, Pinto-Fraga, José, Lista, Simone, Santos-Lozano, Alejandro, Téllez, Nieves |
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| Předmět: |
MULTIPLE sclerosis prevention
EXERCISE physiology MULTIPLE sclerosis SKELETAL muscle DATA analysis HIGH-intensity interval training CLINICAL trials QUESTIONNAIRES FUNCTIONAL status DESCRIPTIVE statistics RESISTANCE training MUSCLE strength NERVE tissue proteins CONTROL groups PRE-tests & post-tests LONGITUDINAL method CYTOPLASM STATISTICS ANALYSIS of variance QUADRICEPS muscle BODY movement COMPARATIVE studies DATA analysis software MUSCLE contraction DISEASE complications |
| Zdroj: | Healthcare (2227-9032); Apr2024, Vol. 12 Issue 8, p837, 14p |
| Abstrakt: | Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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