| Autor: |
Sekiguchi, Kie, Abe, Takaya, Shiomi, Ei, Ikarashi, Daiki, Matsuura, Tomohiko, Maekawa, Shigekatsu, Kato, Renpei, Kanehira, Mitsugu, Takata, Ryo, Sugimura, Jun, Sekiguchi, Takashi, Obara, Wataru |
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| Zdroj: |
Therapeutic Apheresis & Dialysis; Jun2024, Vol. 28 Issue 3, p364-370, 7p |
| Abstrakt: |
Introduction: We aimed to determine whether unfractionated heparin (UH) and low molecular weight heparin (LH) contribute to aberrant carnitine metabolism in patients receiving hemodialysis. Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined. Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change. Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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