Risk factors for amputation in diabetic foot ulcers: A retrospective analysis.

Autor:	Zhang, Xiaoyu, Li, Qiwei, Zhou, Xianpei, Xu, Yu, Shu, Zizhen, Deng, Hongyu
Předmět:	AMPUTATION RISK assessment LEUCOCYTES NEUTROPHIL lymphocyte ratio HIGH density lipoproteins EARLY medical intervention RECEIVER operating characteristic curves T-test (Statistics) RESEARCH funding MULTIPLE regression analysis RETROSPECTIVE studies MULTIVARIATE analysis DESCRIPTIVE statistics ODDS ratio DIABETIC foot ELECTRONIC health records STATISTICS CONFIDENCE intervals DATA analysis software COMPARATIVE studies PREVENTIVE health services C-reactive protein BIOMARKERS DISEASE complications
Zdroj:	International Wound Journal; Apr2024, Vol. 21 Issue 4, p1-10, 10p
Abstrakt:	Diabetic foot ulcers (DFUs) are chronic, difficult‐to‐heal wounds with a very high incidence of amputation. For patients with DFUs, prevention of amputation is crucial. However, the risk factors associated with DFU amputation and the extent to which different risk factors increase the risk of amputation are still uncertain. This study intends to provide a clinical basis for early intervention in DFU by retrospectively analysing the risk factors for DFU amputation. A retrospective analysis of 200 patients with DFUs admitted between October 2019 and October 2023 was conducted. Sixty‐eight of the 200 underwent amputations. The overall amputation rate was 34%. Multiple logistic regression model showed that neutrophil/lymphocyte ratio (OR = 1.943; 95% CI:1.826–2.139), white blood cell (OR = 1.143; 95% CI:1.034–1.267), C‐reactive protein (OR = 1.307; 95% CI:1.113–2.194) and Wagner grading (OR = 2.783; 95% CI: 1.751–4.302) were independent risk factors for amputation, while haemoglobin (OR = 0.742; 95% CI:0.638–0.965) and high density lipoprotein were independent protective factors for amputation (OR = 0.168; 95% CI:0.037–0.716), and further Receiver Operating Characteristic Curve curves showed that they showed high accuracy and were good predictors of amputation of DFUs. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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