| Autor: |
Rodrigues, Cristiana, Laranjeira, Paula, Pinho, Aryane, Silva, Isabel, Silva, Sandra, Coucelo, Margarida, Oliveira, Ana Catarina, Simões, Ana Teresa, Damasio, Ines, Silva, Helena Matos, Urbano, Mafalda, Sarmento-Ribeiro, Ana Bela, Geraldes, Catarina, Domingues, M. Rosário, Almeida, Julia, Criado, Ignacio, Orfao, Alberto, Paiva, Artur |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology; 2024, p1-18, 18p |
| Abstrakt: |
Introduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease. Results and discussion: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vb 5.1 in CD4+ CD20+ T cells in CLL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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