| Autor: |
مریم لوری, ایمان سوری نژاد, ملیکا ناظمی, زهرا قاسمی |
| Zdroj: |
Journal of Aquatic Physiology & Biotechnology; Apr2024, Vol. 11 Issue 4, p15-30, 16p |
| Abstrakt: |
One of the most important secondary metabolites of the marine sponges are steroids. The aim of this study is to investigate the antifungal activity of the steroidal fractions derived from the sponge Axinella sinoxea from the waters around Lark Island in the Persian Gulf. Extraction from sponges was done with acetone and separation of fractions was done by column chromatography with silica gel using a range of solvents with different polarity. Identification of steroidal fractions were done by thin layer chromatography and gas chromatography coupled with mass spectrometry. Then, antifungal properties of the steroids were investigated through determining the minimum inhibition concentration and minimum fungicidal concentration by tubular dilution method against Aspergillus fumigatus and Candida albicans. The identified steroids included compounds of Stigmasta, Ergosta, Cholest and Norgorgosta, which showed different results regarding the growth inhibition and killing of fungi and yeast strains at different experimental doses. Stigmasta and Ergosta showed more antifungal effects against A. fumigatus compared with the other steroids and Ergosta caused the best inhibitory and killing effects against C. albicans compared with the other steroids. In conclusion, promising results were found regarding the antifungal effects of the extracted steroids of the marine sponge A. sinoxea, revealing the necessity of more comprehensive investigations for the synthesis of biomedicines from the marine bioactive compounds. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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