| Abstrakt: |
A recent report from Louisiana State University Health Sciences Center highlights research on the expression of pyruvate kinase M1 (PKM1) and pyruvate kinase M2 (PKM2) in developing, benign, and cancerous prostatic tissues. The study found that PKM2 was the predominant isoform expressed throughout prostate development and cancer progression, with slightly reduced expression in neuroendocrine prostate cancer (NEPCa). PKM1 was mostly expressed in stromal cells and absent in the majority of prostate adenocarcinoma (AdPCa) specimens but present in a subset of NEPCa. These findings provide insights into the metabolic changes in different prostate cancer subtypes. [Extracted from the article] |
