| Abstrakt: |
A recent study analyzed the genetic variants that influence variance in blood cell phenotypes, which are routinely tested in healthcare. The researchers discovered 176 independent genetic loci associated with trait variance, highlighting the role of selection in reducing extreme blood cell phenotypes. They also constructed variance polygenic scores (vPGSs) to stratify individuals based on genetic variability, finding that individuals with lower genetic variability had increased accuracy in predicting blood cell traits. Additionally, the study found that alcohol consumption significantly increased blood cell trait variances. This research provides new insights into the biology and prediction of complex traits. [Extracted from the article] |
