Study Findings from University Health Network Advance Knowledge in Parkinson's Disease (Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson's disease).

Předmět:	PARKINSON'S disease SUBTHALAMIC nucleus CENTRAL nervous system diseases HEALTH care networks BASAL ganglia diseases NEUROLOGICAL disorders
Zdroj:	Pain & Central Nervous System Week; 4/29/2024, p959-959, 1p
Abstrakt:	A recent study conducted by researchers at the University Health Network has shed light on the neural signatures of deep brain stimulation (DBS) in Parkinson's disease. The study found that DBS of the subthalamic nucleus (STN) produces a high-frequency oscillation called evoked resonant neural activity (ERNA), which has been linked to treatment efficacy. The researchers identified that ERNA is associated with temporally-locked neuronal inhibition in the STN and characterized its temporal dynamics. They also localized ERNA to the dorsal STN and assessed its spatial relevance to DBS outcome. This research provides valuable insights into the subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network in Parkinson's disease. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu