| Abstrakt: |
A recent study from Guangdong Medical University explores the genetic and inflammatory factors underlying gestational diabetes mellitus (GDM). The researchers discuss the role of insulin function and genetic variants in GDM development, specifically focusing on genes such as SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK. They propose that these genetic variations may disrupt zinc transport, impairing insulin production and secretion. The study also examines the involvement of inflammatory pathways and the impact of GDM on cardiovascular disease. The researchers emphasize the need for further research to understand the complex interplay between genetics, inflammation, and GDM. This review provides insights into the pathophysiological mechanisms of GDM and offers a foundation for developing strategies to mitigate its impact. [Extracted from the article] |
