Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis.

Autor:	Yu, Lingling, Zhu, Yuan, Geng, Lan, Xu, Yueming, Zhao, Mei
Předmět:	THERAPEUTIC use of vitamin E INFLAMMATION prevention THERAPEUTIC use of vitamin D THERAPEUTIC use of vitamin A BLOOD sugar analysis MEDICAL information storage & retrieval systems GUTTMAN scale GLUTATHIONE PREPROCEDURAL fasting RESEARCH funding FOOD consumption GESTATIONAL diabetes STATISTICAL sampling NUTRITIONAL requirements OXIDATIVE stress TREATMENT effectiveness DESCRIPTIVE statistics META-analysis MEDLINE SYSTEMATIC reviews MEDICAL databases ANTIOXIDANTS ONLINE information services CONFIDENCE intervals C-reactive protein MALONDIALDEHYDE
Zdroj:	British Journal of Nutrition; 5/14/2024, Vol. 131 Issue 9, p1513-1527, 15p
Abstrakt:	We searched PubMed, Web of Science, Embase, The Cochrane Library, China Biomedical Literature Database and other databases from inception to June 2023. The included studies were randomised controlled trials (RCT). The studies were screened by four authors, divided into two independent pairs. A total of eighteen studies were included, including 1362 patients, involving twelve intervention measures. The different nutrients had a significant effect on improving blood glucose, reducing inflammation levels and reducing oxidative stress compared with placebo (P < 0.05). Cumulative probability ranking showed that vitamin A + vitamin D + vitamin E ranked first in lowering fasting blood glucose (standardised mean difference (SMD) = 41.30, 95 % CI (2.07, 825.60)) and postprandial 2-h blood glucose (SMD = 15.19, 95 % CI (4.16, 55.53)). In terms of insulin resistance index, the first highest probability ranking is vitamin D (SMD = 5.12, 95 % CI (0.76, 34.54)). In terms of reducing the high-sensitivity C-reactive protein level, the first in probability ranking is VE (SMD = 2.58, 95 % CI (1.87,3.55)). The results of cumulative probability ranking showed that Mg + Zn + Ca + VD ranked first in reducing TNF-α (SMD = 1.90, 95% CI (0.40, 9.08)) and IL-6 (SMD = 1.83, 95 % CI (0.37, 9.12)). In terms of reducing malondialdehyde levels, the first ranked probability is VB1 (SMD = 4.99, 95 % CI (1.85, 13.46)). Cumulative probability ranking results showed that Ca + VD ranked first in reducing total antioxidant capacity (SMD = 0.66,95 % CI (0.38, 1.15)) and glutathione (SMD = 1.39, 95 % CI (0.43, 4.56)). In conclusion, nutritional interventions have significant effects on improving blood glucose, inflammatory levels and oxidative stress in patients with gestational diabetes. Due to the high uncertainty in the results and differences in the number and quality of studies included, the reliability of the conclusions still needs to be validated by conducting large-sample, high-quality RCT studies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu