Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke.

Autor: Irie, Fumi, Matsuo, Ryu, Mezuki, Satomi, Wakisaka, Yoshinobu, Kamouchi, Masahiro, Kitazono, Takanari, Ago, Tetsuro, Ishitsuka, Takao, Ibayashi, Setsuro, Kusuda, Kenji, Fujii, Kenichiro, Nagao, Tetsuhiko, Okada, Yasushi, Yasaka, Masahiro, Ooboshi, Hiroaki, Irie, Katsumi, Omae, Tsuyoshi, Toyoda, Kazunori, Nakane, Hiroshi, Sugimori, Hiroshi
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Zdroj: Scientific Reports; 4/23/2024, Vol. 14 Issue 1, p1-9, 9p
Abstrakt: Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, including neurological improvement (≥ 4-point decrease in the National Institutes of Health Stroke Scale during hospitalization or 0 points at discharge) and good functional outcomes (modified Rankin Scale score of 0–2) at 3 months, was evaluated using logistic regression analysis and propensity score-matched analysis. Among the participants, 231 (20.1%) were current smokers. The odds ratios (ORs) of favorable outcomes after adjusting for potential confounders were not significantly increased in current smokers (OR 0.85, 95% confidence interval [CI] 0.60–1.22 for neurological improvement; OR 0.95, 95% CI 0.65–1.38 for good functional outcome). No significant association was found in the propensity score-matched cohorts. Smoking cessation is strongly recommended since current smoking was not associated with better outcomes after reperfusion therapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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