Phage-antibiotic combinations to control Pseudomonas aeruginosa–Candida two-species biofilms.

Autor: Manohar, Prasanth, Loh, Belinda, Nachimuthu, Ramesh, Leptihn, Sebastian
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Zdroj: Scientific Reports; 4/23/2024, Vol. 14 Issue 1, p1-11, 11p
Abstrakt: Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed when applying both components together. Most studies however focus on a single pathogen, although in many clinical cases multiple species are present at the site of infection. The aim of this study was to investigate the anti-biofilm activity of phage-antibiotic/antifungal combinations on single- and dual-species biofilms formed by P. aeruginosa and the fungal pathogen Candida albicans. The Pseudomonas phage Motto in combination with ciprofloxacin had significant anti-biofilm activity. We then compared biofilms formed by P. aeruginosa alone with the dual-species biofilms formed by bacteria and C. albicans. Here, we found that the phage together with the antifungal fluconazole was active against 6-h-old dual-species biofilms but showed only negligible activity against 24-h-old biofilms. This study lays the first foundation for potential therapeutic approaches to treat co-infections caused by bacteria and fungi using phage-antibiotic combinations. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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