| Autor: |
Valenzuela-García, Luz I., Ayala-García, Victor M., Ramos-Rosales, Daniel F., Jacquez-Flores, Rayo Emeryt, Urtiz-Estrada, Norma, Hernández, Edna Madaí Méndez, Barraza-Salas, Marcelo |
| Předmět: |
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| Zdroj: |
Archives of Suicide Research; Apr-Jun2024, Vol. 28 Issue 2, p674-685, 12p |
| Abstrakt: |
The main aim of the current study was to investigate whether SKA2 gene expression in the postmortem brain of rs7208505 genotype are altered in suicide victims from a Mexican population. In this study, we report a genetic analysis of expression levels of the SKA2 gene in the prefrontal cortex of the postmortem brain of suicidal subjects (n = 22) compared to subjects who died of causes other than suicide (n = 22) in a Mexican population using RT-qPCR assays. Additionally, we genotyped the rs7208505 polymorphism in suicide victims (n = 98) and controls (n = 88) and we evaluate the association of genotypes for the SNP rs7208505 with expression level of SKA2. The results showed that the expression of the SKA2 gene was significantly higher in suicide victims compared to control subjects (p = 0.044). Interestingly, we observed a greater proportion of allele A of the rs7208505 in suicide victims than controls. Even though there was no association between the SNP with suicide in the study population we found a significative association of the expression level from SKA2 with the allele A of the rs7208505 and suicide. The evidence suggests that the expression of SKA2 in the prefrontal cortex may be a critical factor in the etiology of suicidal behavior. Suicide victims have a higher level of SKA2 gene expression in the brain's prefrontal cortex than control subjects. The SKA2 rs7208505 is not associated with suicide in the Mexican population studied. Allele frequencies for G are higher than allele frequencies for A in our study population. The allele A of the rs7208505 affects the expression values of the SKA2 gene. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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