The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework.

Autor:	Stalinskaya, Alena L., Dengis, Natalia A., Vlasenko, Vasily S., Kulakov, Ivan V.
Předmět:	AROMATIC aldehydes CHALCONES ACETIC acid HYDRAZINES PYRIDINE HYDRAZINE HYDRAZINE derivatives
Zdroj:	Chemistry of Heterocyclic Compounds; Feb2024, Vol. 60 Issue 1/2, p41-47, 7p
Abstrakt:	The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]-oxocino[4,3-b]pyridine with aromatic aldehydes. A subsequent cyclization with hydrazine hydrate in acetic acid led to the corresponding 4,5-dihydro-1H-pyrazole derivatives. An assessment of the resulting derivatives for antitubercular activity was carried out. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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