| Autor: |
Mattsson, Patrik, Cselényi, Zsolt, Forsberg Morén, Anton, Freund-Levi, Yvonne, Wahlund, Lars-Olof, Halldin, Christer, Farde, Lars |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2024, Vol. 98 Issue 4, p1391-1401, 11p |
| Abstrakt: |
Background: Deposits of amyloid-β (Aβ) appear early in Alzheimer's disease (AD). Objective: The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET). Methods: Eight cognitively unimpaired (CU) subjects, 8 with mild cognitive impairment (MCI) and 8 with mild AD were examined with PET and [11C]AZD2184. A data driven cut-point for Aβ positivity was defined by Gaussian mixture model of isocortex binding potential (BPND) values. Results: Sixteen subjects (3 CU, 5 MCI and 8 AD) were Aβ-positive. BPND was lower in subcortical and allocortical regions compared to isocortex. Fifteen of the 16 Aβ-positive subjects displayed Aβ binding in striatum, 14 in thalamus and 10 in allocortical regions. Conclusions: Aβ deposits appear to be widespread in early AD. It cannot be excluded that deposits appear simultaneously throughout the whole brain which has implications for improved diagnostics and disease monitoring. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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