| Abstrakt: |
Objective The connection between total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and stroke risk is controversial. This study aims to examine the connection between the TC/HDL-C ratio and stroke in middle-aged and older individuals who are part of the China Health and Retirement Longitudinal Study (CHARLS). Methods This study conducted a retrospective cohort analysis, enrolling a total of 10,184 participants who met the designated criteria from CHARLS between 2011 and 2012. We then used the Cox proportional-hazards regression model to analyze the relationship between the TC/HDL-C ratio and stroke risk. Using a Cox proportional hazards regression model with cubic spline functions and smooth curve ftting, we were able to identify the non-linear relationship between the TC/HDL-C ratio and stroke occurrence. The sensitivity and subgroup analyses were also performed to investigate the connection between TC/HDL-C ratio and stroke. Results This study revealed a statistically signifcant association between the TC/HDL-C ratio and stroke risk in subjects aged 45 years or older after adjusting for risk factors (HR: 1.05, 95%CI 1.00–1.10, P=0.0410). Furthermore, a nonlinear connection between the TC/HDL-C ratio and stroke risk was detected, with a TC/HDL-C ratio infection point of 3.71. We identifed a signifcant positive connection between the TC/HDL-C ratio and stroke risk, when the TC/ HDL-C ratio was less than 3.71 (HR: 1.25, 95%CI 1.07–1.45, P=0.0039). However, their connection was not signifcant when the TC/HDL-C ratio exceeded 3.71 (HR: 1.00, 95%CI 0.94–1.06, P=0.9232). The sensitivity analysis and subgroup analyses revealed that our fndings were well-robust. Conclusion Our study demonstrated a positive, non-linear connection between the TC/HDL-C ratio and stroke risk in middle-aged and older individuals. There was a signifcant positive connection between the TC/HDL-C ratio and stroke risk, when the TC/HDL-C ratio was less than 3.71. The current research can be used as a guideline to support clinician consultation and optimize stroke prevention measures for middle-aged and older adults. [ABSTRACT FROM AUTHOR] |
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