| Autor: |
Wang, Jing-Wen, Liu, Dong-Yun, Zhang, Hou-Ze, Tan, Zhen, Zheng, Cai-Juan, Chen, Guang-Ying, Nong, Xu-Hua |
| Předmět: |
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| Zdroj: |
Natural Product Research; May2024, Vol. 38 Issue 10, p1711-1718, 8p |
| Abstrakt: |
Chemical investigation of a culture broth from the marine-derived fungus Pyrrhoderma noxium HNNU0524 yielded two new compounds including a drimane-type sesquiterpenoid named pyrrnoxin A (1) and a benzoic acid derivative, pyrrnoxin B (5), together with three related known analogues (2–4). The chemical structures of 1 and 5 were determined by detailed analysis of spectroscopic data, single-crystal X-ray crystallography, quantum mechanics-based DP4+ and ECD calculations. Compounds 2 and 3 moderately inhibited NO production of lipopolysaccharide-induced microglia cells BV2 with IC50 values of 26.6 and 60.5 µM, respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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