Prevalence and prognosis of structural heart disease among athletes with negative T waves and normal transthoracic echocardiography.

Autor: Conte, Edoardo, Pizzamiglio, Francesca, Dessanai, Maria Antonietta, Guarnieri, Gianluca, Ardizzone, Valentina, Schillaci, Matteo, Dello Russo, Antonio, Casella, Michela, Mushtaq, Saima, Melotti, Eleonora, Marchetti, Davide, Volpato, Valentina, Drago, Gabrile, Gigante, Carlo, Sforza, Chiarella, Bartorelli, Antonio L., Pepi, Mauro, Pontone, Gianluca, Tondo, Claudio, Andreini, Daniele
Zdroj: Clinical Research in Cardiology; May2024, Vol. 113 Issue 5, p706-715, 10p
Abstrakt: Introduction: The aim of the present study was to evaluate the prevalence and prognosis of structural heart disease (SHD) among competitive athletes with negative T waves without pathological findings at transthoracic echocardiogram. Methods: From a prospective register of 450 athletes consecutively evaluated during a second-level cardiological examination, we retrospectively identified all subjects with the following inclusion criteria: (1) not previously known cardiovascular disease; (2) negative T waves in leads other than V1–V2; (3) normal transthoracic echocardiogram. Patients underwent cardiac MRI and CT. The primary endpoint was the diagnosis of definite SHD after multimodality imaging evaluation. A follow-up was collected for a combined end-point of sudden death, resuscitated sudden cardiac death and hospitalization for any cardiovascular causes. Results: A total of 55 competitive athletes were finally enrolled (50 males, 90%) with a mean age of 27.5 ± 14.1 years. Among the population enrolled 16 (29.1%) athletes had a final diagnosis of SHD. At multivariate analysis, only deep negative T waves remained statistically significant [OR (95% CI) 7.81 (1.24–49.08), p = 0.0285]. Contemporary identification of deep negative T waves and complex arrhythmias in the same patients appeared to have an incremental diagnostic value. No events were collected at 49.3 ± 12.3 months of follow-up. Conclusions: In a cohort of athletes with negative T waves at ECG, cardiac MRI (and selected use of cardiac CT) enabled the identification of 16 (29.1%) subjects with SHD despite normal transthoracic echocardiography. Deep negative T waves and complex ventricular arrhythmias were the only clinical characteristic associated with SHD diagnosis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: