| Abstrakt: |
A recent study conducted by the National Institutes of Health (NIH) in Bethesda, Maryland, explored the role of melanocortin 4 receptor (MC4R) mutations in obesity. The researchers found that a specific MC4R mutation, known as MC4RF51L, led to obesity, hyperphagia (excessive eating), and increased linear growth in mice. This mutation affected the MC4R/Gq/11 alpha signaling pathway, which is involved in regulating food intake and growth. The study suggests that targeting this pathway with a biased MC4R agonist could be a potential treatment for obesity with limited side effects. [Extracted from the article] |
