Studies from University of Texas MD Anderson Cancer Center Yield New Data on Science (Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade).

Předmět:	IMMUNE checkpoint proteins OVARIAN tumors FUCOSYLATION DATA science HOMOLOGOUS recombination
Zdroj:	Women's Health Weekly; 4/23/2024, p2637-2637, 1p
Abstrakt:	A recent study conducted at the University of Texas MD Anderson Cancer Center has found that targeting branched N-glycans and fucosylation can sensitize ovarian tumors to immune checkpoint blockade (ICB). The researchers discovered that inhibiting branched N-glycans increased the sensitivity of HR-proficient epithelial ovarian cancers (EOCs) to anti-PD-L1 immunotherapy. Additionally, they observed an enrichment of branched N-glycans on HR-proficient EOCs compared to HR-deficient EOCs. These findings suggest that branched N-glycans could be a promising therapeutic target for overcoming immune evasion in HR-proficient EOCs. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu