| Abstrakt: |
A recent study conducted by researchers at the Karlsruhe Institute of Technology (KIT) in Germany has demonstrated the feasibility of using Raman spectroscopy as a tool for monitoring Critical Quality Attributes (CQAs) in biopharmaceutical downstream processes. The study found that Raman spectroscopy, when connected to a Tecan liquid handling station, was able to accurately predict various CQAs, such as fragments, target protein concentration, aggregates, and charge variants. The researchers concluded that this method could be a rapid and effective way to implement in-line CQA monitoring in process development and biomanufacturing, eliminating the need for labor-intensive sample pooling and handling. The study has been peer-reviewed and published in the Journal of Chromatography A. [Extracted from the article] |
