National Cancer Centre Singapore Researcher Has Published New Study Findings on Non-Small Cell Lung Cancer (Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations).

Předmět:	NON-small-cell lung carcinoma SMOKING statistics EPIDERMAL growth factor receptors CANCER patients SMOKING RESEARCH personnel CANCER genetics
Zdroj:	Cancer Weekly; 4/23/2024, p580-580, 1p
Abstrakt:	A new study conducted by researchers at the National Cancer Centre Singapore has found that non-small cell lung cancers (NSCLCs) in both smokers and non-smokers are primarily driven by mutations in certain oncogenes. The study compared the genomic and transcriptomic alterations in NSCLCs from 48 patients with a history of smoking and found that the genomic landscape was similar between smokers and non-smokers. However, NSCLCs in smokers had higher transcriptomic activities related to the regulation of the cell cycle, suggesting that smoking still affects the tumor phenotype independently of genomic alterations. This research provides valuable insights into the genetic factors contributing to NSCLCs and the impact of smoking on tumor development. [Extracted from the article]
Databáze:	Complementary Index
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