| Autor: |
Rordorf, Roberto, Pignalosa, Leonardo, Casula, Matteo, Perna, Enrico, Baroni, Matteo, Garascia, Andrea, Guida, Stefania, Gazzoli, Fabrizio, Pini, Daniela, Cannata, Francesco, Pellegrino, Marta, Vittori, Claudia, De Filippo, Paolo, Malanchini, Giovanni, Vergara, Pasquale, Della Bella, Paolo, Gulletta, Simone, Rordorf, R., Pignalosa, L., Casula, M. |
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| Zdroj: |
Artificial Organs; May2024, Vol. 48 Issue 5, p525-535, 11p |
| Abstrakt: |
Background: Left ventricular assist device (L‐VAD) implantation is increasingly used in patients with heart failure (HF) and most patients also have an implantable cardioverter defibrillator (ICD). Limited data are available on the incidence of ICD therapies and complications in this special setting. The aim of this study was to analyze the real‐world incidence and predictors of ICD therapies, complications and interactions between ICD and L‐VAD. Methods: We conducted a multicenter retrospective observational study in patients with advanced HF implanted with ICD and a continuous‐flow L‐VAD, followed‐up in five advanced HF centers in Northern Italy. Results: A total of 234 patients (89.7% male, median age 59, 48.3% with ischemic etiology) were enrolled. After a median follow‐up of 21 months, 66 patients (28.2%) experienced an appropriate ICD therapy, 22 patients (9.4%) an inappropriate ICD therapy, and 17 patients (7.3%) suffered from an interaction between ICD and L‐VAD. The composite outcome of all ICD‐related complications was reported in 41 patients (17.5%), and 121 (51.7%) experienced an L‐VAD‐related complication. At multivariable analysis, an active ventricular tachycardia (VT) zone and a prior ICD generator replacement were independent predictors of ICD therapies and of total ICD‐related complications, respectively. Conclusions: Real‐world patients with both L‐VAD and ICD experience a high rate of ICD therapies and complications. Our findings suggest the importance of tailoring device programming in order to minimize the incidence of unnecessary ICD therapies, thus sparing the need for ICD generator replacement, a procedure associated to a high risk of complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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