Chemometric Assisted UV-Vis Spectroscopic Study of Photostability of Some Beta-Blockers With Multivariate Curve Resolution-alternating Least Square (MCR-ALS) Method Using Soft and Hard Modelling Approach.

Autor: Dakhni, Bariz, Kulkarni, Shounak, Ringe, Shruti, Sutar, Abhijeet
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Zdroj: Pharmakeftiki; Oct-Dec2023, Vol. 35 Issue 4, p47-56, 10p
Abstrakt: This article presents a study on the photodegradation of beta-blocker drugs, with a specific focus on propranolol. The researchers used UV spectra to analyze the susceptibility of the drugs to degradation and employed chemometric approaches to determine the number of chemical components present in the samples. The study found that propranolol showed significant degradation and the formation of new products, possibly due to its unique chemical structure. The results provide valuable insights into the photodegradation mechanisms of beta-blocker drugs. The article also references other studies on photodegradation and stability analysis of pharmaceutical drugs. [Extracted from the article]
Databáze: Complementary Index