| Autor: |
Boccuto, Fabiola, Carabetta, Nicole, Cacia, Michele Antonio, Kanagala, Sai Gautham, Panuccio, Giuseppe, Torella, Daniele, De Rosa, Salvatore |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Investigation; May2024, Vol. 54 Issue 5, p1-19, 19p |
| Abstrakt: |
Background: Embolization of debris can complicate transcatheter aortic valve implantation (TAVI) causing stroke. Cerebral embolism protection (CEP) devices can divert or trap debris. Purpose: To evaluate the efficacy of CEP during TAVI vs the standard procedure. Data Sources: PubMed, SCOPUS and DOAJ 1/01/2014–04/12/2023. Study Selection: Randomized and observational studies comparing CEP versus standard TAVI, according to PRISMA. Primary outcome: stroke. Secondary outcomes: death, bleeding, vascular access complications, acute kidney injury and infarct area. Data Extraction: Two investigators independently assessed study quality and extracted data. Data Synthesis: Twenty‐six articles were included (540.247 patients). The primary endpoint was significantly lower (RR = 0.800 95%CI:0.682–0.940; p = 0.007) with CEP. Similarly, death rates were significantly lower with CEP (RR = 0.610 95%CI:0.482–0.771; p < 0.001). No difference was found for bleeding (RR = 1.053 95%CI:0.793–1.398; p = 0.721), vascular complications (RR = 0.937 95%CI:0.820–1.070; p = 0.334) or AKI (RR = 0.982 95%CI:0.754–1.279; p = 0.891). Conclusions: Use of CEP during TAVI is associated with improved outcomes. Future studies will identify patients who benefit most from CEP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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