| Autor: |
Mandic, Ante, Kraljevic, Ivana, Skoric Polovina, Tanja, Zibar Tomsic, Karin, Dusek, Tina, Balasko, Annemarie, Solak, Mirsala, Kastelan, Darko |
| Předmět: |
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| Zdroj: |
Experimental & Clinical Endocrinology & Diabetes; Apr2024, Vol. 132 Issue 4, p216-220, 5p |
| Abstrakt: |
Objective This study aimed to assess the diagnostic performance of99m Tc-sestamibi SPECT/CT and18 F-choline PET/CT in detecting hyperfunctioning parathyroid glands in patients undergoing surgery for primary hyperparathyroidism (PHPT). Methods A retrospective analysis was conducted on patients who underwent PHPT-related surgery between April 2019 and May 2022. The study focused on patients undergoing either99m Tc-sestamibi SPECT/CT (81 patients) or18 F-choline PET/CT (33 patients) scans before surgery to pinpoint hyperfunctioning parathyroid gland(s). In the majority of patients,18 F-choline PET/CT was performed after negative or inconclusive findings on99m Tc-sestamibi SPECT/CT. Pathohistological reports were utilized as the reference standard for evaluating the accuracy of the imaging findings. Results The study encompassed 83 patients (70 females, 84.3%) with an average age of 57.2 years (24–80 years). The pathohistological analysis identified a total of 98 glands. In a per-lesion analysis, the detection rate of99m Tc-sestamibi SPECT/CT was 57% (95% CI 45.3–68.1), while the detection rate of18 F-choline PET/CT was 90.3% (95% CI 74.3–98.0). Conclusion The results of our study showed the significant usefulness of18 F-choline PET/CT in patients with negative or inconclusive results of99m Tc-sestamibi SPECT/CT in accurately locating hyperfunctioning parathyroid glands in PHPT patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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