Clinical and Serologic Phenotyping and Damage Indices in Patients With Systemic Lupus Erythematosus With and Without Fibromyalgia.

Autor:	Corbitt, Kelly, Carlucci, Philip M., Cohen, Brooke, Masson, Mala, Saxena, Amit, Belmont, H. Michael, Tseng, Chung‐E, Barbour, Kamil E., Gold, Heather, Buyon, Jill, Izmirly, Peter
Předmět:	T-test (Statistics) RESEARCH funding FIBROMYALGIA QUESTIONNAIRES FISHER exact test SYSTEMIC lupus erythematosus MANN Whitney U Test DESCRIPTIVE statistics RACE LONGITUDINAL method SURVEYS SEROLOGY COMPARATIVE studies PHENOTYPES DISEASE complications
Zdroj:	ACR Open Rheumatology; Apr2024, Vol. 6 Issue 4, p172-178, 7p
Abstrakt:	Objective: Given fibromyalgia (FM) frequently co‐occurs with autoimmune disease, this study was initiated to objectively evaluate FM in a multiracial/ethnic cohort of patients with systemic lupus erythematosus (SLE). Methods: Patients with SLE were screened for FM using the 2016 FM classification criteria during an in‐person rheumatologist visit. We evaluated hybrid Safety of Estrogens in Lupus National Assessment (SELENA)‐SLE Disease Activity Index (SLEDAI) scores, SLE classification criteria, and Systemic Lupus International Collaborating Clinics damage index. We compared patients with and without FM and if differences were present, compared patients with FM with patients with non‐FM related chronic pain. Results: 316 patients with SLE completed the FM questionnaire. 55 (17.4%) met criteria for FM. The racial composition of patients with FM differed from those without FM (P = 0.023), driven by fewer Asian patients having FM. There was no difference in SLE disease duration, SELENA‐SLEDAI score, or active serologies. There was more active arthritis in the FM group (16.4%) versus the non‐FM group (1.9%) (P < 0.001). The Widespread Pain Index and Symptom Severity Score did not correlate with degree of SLE activity (r = −0.016; 0.107) among patients with FM or non‐FM chronic pain (r = 0.009; −0.024). Regarding criteria, patients with FM had less nephritis and more malar rash. Systemic Lupus International Collaborating Clinics damage index did not differ between groups. Conclusion: Except for arthritis, patients with SLE with FM are not otherwise clinically or serologically distinguishable from those without FM, and Widespread Pain Index and Symptom Severity Score indices do not correlate with SLEDAI. These observations support the importance of further understanding the underlying biology of FM in SLE. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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