Melioidosis of the Central Nervous System: Impact of the bimABm Allele on Patient Presentation and Outcome.
Autor: | Gora, Hannah, Hasan, Tasnim, Smith, Simon, Wilson, Ian, Mayo, Mark, Woerle, Celeste, Webb, Jessica R, Currie, Bart J, Hanson, Josh, Meumann, Ella M |
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Předmět: |
MELIOIDOSIS
MICROBIAL virulence RESEARCH funding BURKHOLDERIA infections MENINGITIS POLYMERASE chain reaction COMPUTED tomography KRUSKAL-Wallis Test FISHER exact test LOGISTIC regression analysis CENTRAL nervous system EVALUATION of medical care MAGNETIC resonance imaging CHI-squared test DESCRIPTIVE statistics ODDS ratio ENCEPHALITIS CONFIDENCE intervals DATA analysis software ALLELES BRAIN abscess SEQUENCE analysis |
Zdroj: | Clinical Infectious Diseases; 4/15/2024, Vol. 78 Issue 4, p968-975, 8p |
Abstrakt: | Background The autotransporter protein Burkholderia intracellular motility A (BimA) facilitates the entry of Burkholderia pseudomallei into the central nervous system (CNS) in mouse models of melioidosis. Its role in the pathogenesis of human cases of CNS melioidosis is incompletely defined. Methods Consecutive culture-confirmed cases of melioidosis at 2 sites in tropical Australia after 1989 were reviewed. Demographic, clinical, and radiological data of the patients with CNS melioidosis were recorded. The bimA allele (bimA |
Databáze: | Complementary Index |
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