| Abstrakt: |
A recent study conducted at the University of Manchester explores the phenomenon of polymorphism in organic compounds, specifically focusing on the antiviral drug ritonavir. Polymorphism refers to the ability of a compound to crystallize in different forms, which can have significant implications for drug delivery and utilization. The researchers discovered that ritonavir exhibits disappearing polymorphs, where its desired form can no longer be produced after the initial nucleation of an unwanted form. However, they also found that the disappearing polymorph and the desired form can be consistently produced through ball-milling under different environmental conditions. This research highlights the potential of mechanochemistry in polymorph discovery and control, particularly for complex flexible drug compounds like ritonavir. [Extracted from the article] |
