| Abstrakt: |
Researchers at Singapore General Hospital have conducted a study on connective tissue cells, specifically mesenchymal stem/stromal cells (MSCs) and their exosomes. MSC exosomes have potential therapeutic applications due to their non-living nature and smaller size. However, the study found that standard radio-iodine labeling protocols used to track the biodistribution of exosomes impaired their functional integrity. The iodination methods used in the study were found to affect the enzymatic activity of CD73 on MSC exosomes, suggesting that the biodistribution of iodinated exosomes may not accurately reflect their functional state. [Extracted from the article] |
