| Autor: |
Al-Tamimi, Jameel, Ebaid, Hossam, Hassan, Iftekhar, Habila, Mohamed, Al Malahi, Nawal M., Alhazza, Ibrahim M. |
| Předmět: |
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| Zdroj: |
Indian Journal of Animal Research; Mar2024, Vol. 58 Issue 3, p470-477, 8p |
| Abstrakt: |
Background: To investigate the therapeutic effects of a combination of citric acid and Se-NPs against carbon tetrachloride (CCl4)-induced renal damage in rats. Methods: Twenty-four rats were divided into three groups (n=8 each). Group 1 (control) received the vehicle, while Group 2 received a single dose of 1 ml/kg CCl4 in liquid paraffin (1:1 volume) via intraperitoneal injection. Group 3 was administered a single dose of 1 ml/kg CCl4 in liquid paraffin and then treated twice a week for three weeks with a dose of 2.5 mg/kg Se-NPs. One-way ANOVA and Tukey's method were used to compare the overall effects of each treatment. Result: CCL4 elevated MDA levels and decreased GSH levels in group 2 animals compared with those in the control group. Se-NPs significantly restored the oxidative stability in group 3. We found that CCL4 significantly increased its effect on renal function, whereas Se-NPs restored the renal structure affected by CCL4. As a result, Se-NPs can potentially reduce the markers of renal injury caused by CCl4, while also restoring oxidative stability and renal structure and function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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