| Autor: |
Abakar, Mudathir Abdelshafea Abdelkareem, Hamad, Daralnaeem Hassan Ali, Faisal, Eman, Omer, Hashim Mohamed Fad-Alla, Faki, Mahmoud Taha Mohamed, Idris, Abdellla Esmail Mohammed, Omer, Rouwida, Osman, Zeinab, Elhassan, Entesar Ahmed Gaffar, Abrahim-Holie, Mohamed Ahmed, Hakami, Mohammed Ageeli, Alghamdi, Abdullah, Alfahed, Abdulaziz, Aloraini, Ghfren Suliman, Alharthi, Nahed Sail, Waggiallah, Hisham Ali |
| Předmět: |
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| Zdroj: |
Journal of Medicine & Life; Dec2023, Vol. 16 Issue 12, p1844-1851, 8p |
| Abstrakt: |
Coronavirus disease 2019 (COVID-19) is a severe and infectious respiratory condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This case-control study aimed to evaluate serum levels of various immunological markers in patients with COVID-19 compared to those with bacterial pneumonia and a healthy control group. Serum samples were collected from adult participants across various COVID-19 isolation centers, including Kassala State and Ahmed Gasim Hospital, between April and June 2021. The study included 70 patients diagnosed with COVID-19, 30 with bacterial pneumonia, and 50 healthy controls. Serum levels of C-reactive protein (CRP), complement components C3 and C4, and cytokines IL-8, IL-10, IL-12, TNF-α, and IFN-γ were measured using standard reagent kits. Serum level of CRP was significantly elevated in both bacterial pneumonia and COVID-19 but significantly higher among patients with bacterial pneumonia. C3 and C4 were also increased in both patient groups, with C3 significantly higher in bacterial pneumonia. IL-8, IL-10, IL-12, TNF-α, and IFN-γ were significantly increased in bacterial pneumonia and SARS-Cov-2 compared to healthy controls. However, IFN-γ was significantly increased among patients with COVID-19 than patients with bacterial pneumonia. This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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